Raw Material Overview

Ceramosides®
Wheat Germ Extract
CERAMOSIDES™ is a French-origin wheat extract approved by the MFDS (Ministry of Food and Drug Safety)
for dual functionalities: 'skin hydration improvement' and 'UV-induced skin damage improvement.
Clinical studies confirm efficacy in enhancing skin barrier function and reducing moisture loss even at a low daily dose (30mg/day).
Its high phytoceramide content demonstrates potential benefits for both skin health and hair growth stimulation.
  • MFDS individually recognized ingredient (No. 2025-11) dual functionality approved

    - May help improve skin hydration
    - May help maintain skin health against UV-induced skin damage

  • Clinical trial (8 weeks)

    Significant increase in skin hydration and elasticity, skin firmness; significant reduction in TEWL, skin roughness (Ra,Rz), wrinkle depth (Sv) confirmed

  • Rapid effect

    Significant improvement confirmed within 14 days

Material Name Wheat Germ Extract (No. 2025-11)
Raw Material Wheat (Triticum aestivum L., Part Used: Seed)
Daily Intake 30 mg/day (as wheat germ extract)
Functionality May improve skin hydration / May help maintain skin health against UV-induced damage
Marker Component Glucosylceramide
Human Trial Duration 8 weeks
Human Clinical Trial Results

  • Test Material

    Wheat Germ Extract
    (Ceramosides®)

  • Study Design

    Subjects with dry skin and
    signs of intrinsic/photoaging

  • Duration & Dosage

    8 weeks

CERAMOSIDES® significantly improved skin hydration, reduced TEWL,
and enhanced elasticity in subjects with dry/intrinsic/photoaged skin.
Skin hydration
TEWL reduction
Skin elasticity
  • Placebo group
  • Control group
  • Test group
CERAMOSIDES® significantly improved skin smoothness, reduced roughness,
and decreased wrinkle depth in the same cohort.
Skin smoothness
Roughness reduction
Wrinkle depth
  • Placebo group
  • Control group
  • Test group
Wheat germ extract (CERAMOSIDES®) showed significant improvement effects in skin hydration, transepidermal water loss, and skin elasticity in human clinical trials targeting postmenopausal women with dry skin and signs of intrinsic or photoaging.
Hydration
TEWL reduction
Elasticity
  • Placebo group
  • Control group
  • Test group
Wheat germ extract (CERAMOSIDES®) showed significant improvement effects in skin smoothness, roughness, and wrinkle depth in human clinical trials targeting postmenopausal women with dry skin and signs of intrinsic or photoaging.
Smoothness
Roughness reduction
Wrinkle depth
  • Placebo group
  • Control group
  • Test group
Animal Study Results
  • Test Material

    Wheat Germ Extract
    (Ceramosides®)

  • Study Design

    UV-B-induced wrinkle/skin dryness model with oral administration at varying concentrations

  • Duration & Dosage

    8 weeks

CERAMOSIDES® reduced wrinkles, decreased epidermal thickness,
and increased skin hydration in UV-B-induced animal models.
CERAMOSIDES® demonstrated significant antioxidant and anti-inflammatory effects.
Increased anti-inflammatory enzyme activity
Suppressed UV-induced inflammatory response
CERAMOSIDES® modulated the expression of wrinkle formation (Gene A)
and hydration-related genes (Genes B–G).
Competitive Advantages
Additional Research Status

Completed Hair & Scalp Clinical Trial

  • Test Material

    Wheat Germ Extract
    (Ceramosides®)

  • Study Design

    66 healthy Caucasian women
    aged 24–64

  • Duration & Dosage

    Wheat Germ Extract(Ceramosides®)
    30 mg/day for 12 weeks

Telogen Hair Density
Anagen Hair Density
Telogen Hair Ratio
Anagen Hair Ratio
  • Placebo group
  • WPLC group
Evolution of parameters evaluated by phototrichograms. Results are presented as mean ± SEM with °p < 0.05, °°p < 0.01 and
°°°p < 0.001 for the intra-group statistical significance versus D0, and *p < 0.05, **p < 0.01 and ***p < 0.001 for the inter-groups statistical significance.
  • 01
    Hair Density

    Reduced hair loss from Week 8

  • 02
    Diameter

    Increased hair shaft thickness

  • 03
    Elongation

    Improved hair elasticity vs.
    placebo from Week 12

  • 04
    Growth

    Significant improvement vs.
    placebo from Week 12

Hair Pull Test (Hairs Shed)
Time point Placebo group WPLC group Significance
versus placebo
D0 14.3 ± 0.7 14.9 ± 0.6
D56 (8 week) 13.5 ± 0.8 12.5 ± 0.6 (p = 0.028)   p = 0.046
D84 (12 week) 8.5 ± 0.3 (p < 0.001) 7.6 ± 0.3 (p < 0.001)   p = 0.052
Note: Results are reported as mean ± SEM. In between brackets, is the intra-group significance of the evolution versus D0.
Hair diameter, length, and growth
Parameter Time point Placebo group WPLC group Significance
versus placebo
Diameter (μm) D0 64 ± 2 63 ± 1
D84 (12 week) 65 ± 2 66 ± 2 (p = 0.076)
Elongation (% of initial length) D0 45.5 ± 0.6 44.1 ± 0.7
D84 (12 week) 45.2 ± 0.5 45.2 ± 0.6 (p = 0.008)   p = 0.013
Growth (length after shaving, cm) D84 (12 week) 3.2 ± 0.1 3.6 ± 0.1   p < 0.001
Note: Results are reported as mean ± SEM. In between brackets, is the intra-group significance of the evolution versus D0.
References