Raw Material Overview

BENESOMNO™
Lime Peel Extract
BENESOMNO is the world’s first and only citrus-derived sleep health ingredient that may support sleep quality.
It is 100% plant-based and safe, with proven sleep benefits through animal studies and human clinical trials.
  • MFDS individually recognized ingredient (No. 2025-26)
  • Manufactured using a patented extraction method to isolate sleep-enhancing core components from Mexican lime (Citrus aurantifolia) peel
  • Reduces sleep latency / Increases total sleep duration / Enhances NREM sleep
  • Patents filed and registered domestically and internationally
Material Details Lime Peel Extract (No. 2025-26)
Raw Material Lime (Citrus aurantifolia (Christm) Swingle, Part Used: Fruit peel)
Dosage 300 mg/day
Functionality May support sleep health
Marker Component Vicenin-2
Human Trial Duration 2 weeks
Human Clinical Trial Results
  • Test Material

    SLPS (standardized lime peel supplement)
    = Lime Peel Extract

  • Study Design

    2-week randomized, double-blind,
    placebo-controlled trial involving
    80 adults (aged 19–65)

  • Duration & Dosage

    1 capsule (300 mg) daily for 2 weeks

Statistically significant improvements in sleep efficiency (SE), sleep latency (SL), total sleep time (TST),
and wake after sleep onset (WASO) observed via polysomnography.
Source: Randomized, Double-Blind, Placebo-Controlled Clinical Trial Report on the Effects and Safety of Lime Peel Extract for Sleep Health Improvement
Animal Study Results
  • Test Material

    SLPS (standardized lime peel supplement)
    = Lime Peel Extract

  • Study Design

    ICR mice

  • Duration & Dosage

    1 day

In sleep-accelerated animal models, SLPS significantly reduced sleep latency and increased sleep duration,
comparable to the positive control zolpidem.
Source: Kim, S., Kim, D., Lee, J., Han, J. K., Um, M. Y., Jung, J. H., ... & Cho, S. (2024). Novel neuropharmacological activity of citrus lime (Citrus aurantifolia): A standardized lime peel supplement enhances non-rapid eye movement sleep by activating the GABA type A receptor. Biomedicine & Pharmacotherapy, 179, 117410.
Mechanism of Action

Lime peel extract activates the GABAA receptor by binding to its core site (GABA-binding site).
This triggers Cl⁻ ion influx into neurons, inhibiting neuronal excitation
and promoting natural sedation and sleep induction.

Patents
  • Korea Registration
  • USA
    Applied

    (2023. 04. 25)

  • EU
    Applied

    (2023. 05. 01)

  • CHINA
    Applied

    (2023. 10. 09)

Publications